Tyrion says the line to Tywin a little after 2:00 ...
This scene is from Game of Thrones season 3 episode 1.
Stashed in: Best of GoT, @mrpeterdinklage
So Tywin never wanted Tyrion to rule Casterly Rock.
And Tywin blames Tyrion for the death of Tywin's wife Joanna during Tyrion's childbirth.
Reddit comments: http://reddit.com/r/gameofthrones/co...
Whoa, this is worth watching in light of the season 4 finale!
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Sickly little boys sometimes become powerful men. ~Littlefinger