Low-calorie sweetener use is independently associated with heavier relative weight, larger waist, and higher incidence of abdominal obesity.
Adam Rifkin stashed this in Weight Loss
The science of the cohort study: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167241
This science suggests that low-calorie sweetener use may not be an effective means of weight control, based on a study of 1,454 participants over 10 years.
How the body responds to artificial sweeteners:
Low-calorie sweeteners certainly have fewer calories; however, our study suggests that they may have metabolic activity that is pro-obesogenic — especially for abdominal adiposity — and this hypothesis should be actively researched.