Stashed in: Science!, Hip Hop, Best Videos, @alyankovic, @neiltyson, G4!, Music Videos, Rap, Epic!, Rap Battles!
Yes, that's Weird Al Yankovic as Isaac Newton.
Reddit comments: http://reddit.com/r/videos/comments/...
The "We got a badass over here" meme is actually from a video of Neil deGrasse Tyson talking about what an actual badass Newton was:
(gif is from 1:30)