Kinesin (a motor protein) pulling a vesicle along cytoskeletal filament gif
Geege Schuman stashed this in Science
WELL YOU CAN TELL BY THE WAY I USE MY WALK, I'M A WOMAN'S MAN, NO TIME TO TALK
Me, I'm just a protein. You can tell me by the way I walk!
Holy crap, is this for real?!?!
I can't find it trending or sourced from anything other than Imgur, Reddit, and 9Gag. Somebody must have done the simulation. I'm guessing it's some visualization done for a research project (GPUs) based on crystal growth and not an actual video of it working.
Seems like... they walk!
Here's the whole video:
And here's what the Encyclopedia Galactica has to say... A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport. Most kinesins walk towards the plus end of a microtubule, which, in most cells, entails transporting cargo from the centre of the cell towards the periphery. This form of transport is known as anterograde transport. In contrast, dyneins are motor proteins that move toward the microtubules' minus end.
Motor proteins fulfill the role of transporting large cargo about the cell to their required destinations. Kinesins are motor proteins that transport such cargo by walking unidirectionally along microtubuletracks hydrolysing one molecule of adenosine triphosphate (ATP) at each step. It was thought that ATP hydrolysispowered each step, the energy released propelling the head forwards to the next binding site. However, it has been proposed that the head diffuses forward and the force of binding to the microtubule is what pulls the cargo along.
Kinesin accomplishes transport by "walking" along a microtubule. Two mechanisms have been proposed to account for this movement.
- In the "hand-over-hand" mechanism, the kinesin heads step past one another, alternating the lead position.
- In the "inchworm" mechanism, one kinesin head always leads, moving forward a step before the trailing head catches up.
Despite some remaining controversy, mounting experimental evidence points towards the hand-over-hand mechanism as being more likely
AWESOME!! Thanks, Mr. Data.
There's something Sisyphusian about the gif...
Because it never ends?
Yup, and it's performing a similar task.
A vesicle is not a boulder!
It's all relative, man!