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A crowdsourced study of 450,000 customers of 23andMe has uncovered the first major trove of genetic clues to the cause of depression.

Stashed in: Brain, Awesome, MIT TR, Depression, Depression, Genomics, Medical Breakthroughs, Crowdsourcing, Mental Health, Mental Health, DNA, DNA, Self Test

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The study, the largest of its kind, detected 15 regions of human genome linked to a higher risk of struggling with serious depression. 

The study was carried out by drug giant Pfizer as part of an alliance with 23andMe, the California company whose gene reports have been purchased by more than 1.2 million people.

So far the vast majority of efforts to locate genetic risks for depression have failed, probably because the efforts have been too small to find anything.

“Everyone is recognizing that this is a numbers problem,” says Ashley Winslow, formerly a neuroscientist at Pfizer and now the director of neurogenetics at the Orphan Disease Center at the University of Pennsylvania. Winslow led the research effort. “It’s hard if not impossible to get to the numbers that we saw in the 23andMe study.”

The results emerged from what is termed a “genome-wide association study.” In this approach, the DNA of many people with a disease is compared to that of healthy controls, using a computerized search. Any genetic differences appearing more often in sick people can hint at what genes are involved.

This gene-hunting tactic has led to important insights into diabetes, schizophrenia, and other common diseases. But depression has remained mostly untouched, until now. Previously, a study in 6,000 severely depressed Chinese women located two signals in the genome, but other surveys came up empty.

“The big story is that 23andMe got us over the inflection point for depression,” says Douglas Levinson, a psychiatrist and gene researcher at Stanford University involved with the Psychiatric Genomics Consortium, another gene-hunting group. “That is exciting. It makes us optimistic that we are finally there.”

23andMe has sold more than a million gene-test kits. The product, costing $199, is mostly for entertainment, like finding out about one’s ethnic background. But more than half of its customers have agreed to allow their DNA to be used in further research and answer survey questions about their health.

Through its surveys, the company was able to locate more than 141,000 people who said they’d been diagnosed with depression. That is about 10 times more than the next-largest depression study ever carried out, says Levinson. DNA data on another 337,000 23andMe customers who reported no depression were used as controls.

The need for ever larger databases is keenly felt by geneticists. At their urging, the U.S. government this year began implementing plans for a million-person precision medicine database. The genetic risk for depression is actually due to hundreds of genes, each having a very small effect.

Top Reddit comment:

I'm amazed at just how much data that 23andMe has managed to accumulate. As someone who studies genomics, it's literally just a treasure trove waiting to be picked through. With that much data, you could search for regions of the genome correlated with a bunch of diseases and disorders we don't really understand or want to study further. I hope 23andMe continues to partner with companies and universities to do this sort of research. It could be a game-changer.

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