"We applied multivariate genetics techniques to a sample of 3,412 monozygotic and dizygotic twins from the United Kingdom and 1,300 monozygotic and dizygotic twins from the United States to examine whether genetic factors account for part of the covariance between the Big Five personality characteristics and the tendency to be an entrepreneur. We found that common genes influenced the phenotypic correlations between only Extraversion and Openness to Experience and the tendency to be an entrepreneur. Although the phenotypic correlations between the personality characteristics and the tendency to be an entrepreneur were small in size, genetic factors accounted for most of them. "

http://psycnet.apa.org/journals/apl/95/6/1154

I'm having trouble parsing this.

First I have to learn the Big Five personality characteristics...

1. Openness: This trait features characteristics such as imagination and insight, and those high in this trait also tend to have a broad range of interests.

2. Conscientiousness: Common features of this dimension include high levels of thoughtfulness, with good impulse control and goal-directed behaviors. Those high in conscientiousness tend to be organized and mindful of details.

3. Extraversion: This trait includes characteristics such as excitability, sociability, talkativeness, assertiveness and high amounts of emotional expressiveness.

4. Agreeableness: This personality dimension includes attributes such as trust, altruism, kindness, affection, and other prosocial behaviors.

5. Neuroticism: Individuals high in this trait tend to experience emotional instability, anxiety, moodiness, irritability, and sadness.

So if the point is that being extraverted, agreeable, conscientious, neurotic, and open, are correlated with entrepreneurism, then anecdotally I can tell you that YES those traits describe many entrepreneurs I know.

Aside: acronyms for the big five include OCEAN and CANOE. :)