I find the image above -- representation of a 9-nanometer azotosome, about the size of a virus, with a piece of the membrane cut away to show the hollow interior -- mesmerizing.

1000 Reddit comments includes an Explain Like I'm Five:

http://reddit.com/r/science/comments/2xekem/life_not_as_we_know_it_possible_on_saturns_moon/

Fascinating model:

A new type of methane-based, oxygen-free life form that can metabolize and reproduce similar to life on Earth has been modeled by a team of Cornell University researchers.

Taking a simultaneously imaginative and rigidly scientific view, chemical engineers and astronomers offer a template for life that could thrive in a harsh, cold world - specifically Titan, the giant moon of Saturn. A planetary body awash with seas not of water, but of liquid methane, Titan could harbor methane-based, oxygen-free cells.

Their theorized cell membrane, composed of small organic nitrogen compounds and capable of functioning in liquid methane temperatures of 292 degrees below zero, is published in Science Advances, Feb. 27. The work is led by chemical molecular dynamics expert Paulette Clancy and first author James Stevenson, a graduate student in chemical engineering. The paper's co-author is Jonathan Lunine, director for Cornell's Center for Radiophysics and Space Research.

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On Earth, life is based on the phospholipid bilayer membrane, the strong, permeable, water-based vesicle that houses the organic matter of every cell. A vesicle made from such a membrane is called a liposome. Thus, many astronomers seek extraterrestrial life in what's called the circumstellar habitable zone, the narrow band around the sun in which liquid water can exist. But what if cells weren't based on water, but on methane, which has a much lower freezing point?

The engineers named their theorized cell membrane an "azotosome," "azote" being the French word for nitrogen. "Liposome" comes from the Greek "lipos" and "soma" to mean "lipid body;" by analogy, "azotosome" means "nitrogen body."

The azotosome is made from nitrogen, carbon and hydrogen molecules known to exist in the cryogenic seas of Titan, but shows the same stability and flexibility that Earth's analogous liposome does. This came as a surprise to chemists like Clancy and Stevenson, who had never thought about the mechanics of cell stability before; they usually study semiconductors, not cells.

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Excited by the initial proof of concept, Clancy said the next step is to try and demonstrate how these cells would behave in the methane environment - what might be the analogue to reproduction and metabolism in oxygen-free, methane-based cells.

Lunine looks forward to the long-term prospect of testing these ideas on Titan itself, as he put it, by "someday sending a probe to float on the seas of this amazing moon and directly sampling the organics."

Stevenson said he was in part inspired by science fiction writer Isaac Asimov, who wrote about the concept of non-water-based life in a 1962 essay, "Not as We Know It."

Said Stevenson: "Ours is the first concrete blueprint of life not as we know it."