G3PP enzyme that 'stops sugar being stored as fat' is identified by scientists...
Adam Rifkin stashed this in Science!
G3PP enzyme can 'zap' excess sugar in body, preventing it turning to fat
Stops the body's cells being poisoned by chemicals produced when they are overloaded with sugar, University of Montreal scientists said
Could pave the way for obesity treatment and those to help diabetics
Researchers have discovered an important, previously unknown step in the metabolism of sugar that could have applications for treating obesity or type 2 diabetes down the road.
In a study published January 11 in the journal Proceedings of the National Academy of Sciences, researchers identified an enzyme present in all mammals, including humans, that prevents excessive sugar from over-accumulating in and causing damage to bodily cells. This enzyme, with the acronym G3PP (glycerol-3-phosphate phosphatase), turns a crucial by-product of glucose into glycerol, which can be excreted from the body in the urine. That stands in contrast to the majority of the other chemicals involved in the metabolic cycle, which cannot bypass the cell’s lipid membrane.
It’s a rare thing, at least in recent history, to describe a new metabolic enzyme that’s present in all mammals and all parts of the body, says Marc Prentki, study senior author and scientist at the University of Montreal Hospital Research Center.