There's been some incredible upsets in round 1 of 2016:

#12 Yale beat #5 Baylor.

#12 Arkansas Little Rock beat #5 Purdue.

#11 Wichita State beat #6 Arizona.

#11 Gonzaga beat #6 Seton Hall.

#10 Syracuse beat #7 Dayton.

And my two favorites...

#13 Hawaii beat #4 Cal.

#15 Middle Tennessee beat #2 Michigan State.

That last one might be the biggest NCAA upset of all time.

Everyone's bracket is busted. No one is getting a perfect score this year!

See also:

https://reddit.com/r/CollegeBasketball/comments/4b07o6/there_were_1766_perfect_brackets_left_before/

Yes, biggest upset of all time:

http://pandawhale.com/post/71178/michigan-state-loses-in-most-shocking-first-round-march-madness-upset-ever

Taurean Prince highlights from the game:

420 Reddit comments:

https://reddit.com/r/videos/comments/4aw9ad/how_did_yale_out_rebound_baylor/

Where is that school, anyway?

https://fivethirtyeight.com/features/the-ncaa-tournaments-most-where-the-hell-is-that-college-colleges-ranked/