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Michigan State Loses in Most Shocking First-Round March Madness Upset Ever.

Stashed in: So you're saying there's a chance...., Nate Silver, Michigan, March Madness!

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Michigan State was favored over Middle Tennessee in the game by 16.5 points, which makes this the fourth-biggest tourney upset of the last 20 years in terms of point spread*—but it's possibly the most surprising ever when you consider that Michigan State was widely considered underrated as a No. 2 seed and was a co-favorite to win the entire tournament according to some Vegas odds. (It's theeighth-ever 15-seed victory over a two-seed.)

Nate Silver did say a 16 seed was due.

Middle Tennessee was practically a 16 seed.

Two record upsets in Michigan in one week!! 

Not a good week for Michiganers. 

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