Michigan State Loses in Most Shocking First-Round March Madness Upset Ever.
Geege Schuman stashed this in March Madness 2016
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Michigan State was favored over Middle Tennessee in the game by 16.5 points, which makes this the fourth-biggest tourney upset of the last 20 years in terms of point spread*—but it's possibly the most surprising ever when you consider that Michigan State was widely considered underrated as a No. 2 seed and was a co-favorite to win the entire tournament according to some Vegas odds. (It's theeighth-ever 15-seed victory over a two-seed.)
Nate Silver did say a 16 seed was due.
Middle Tennessee was practically a 16 seed.