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Fridge-sized machine makes prescription drugs on demand...

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Bioprinting is a nascent technology but it has huge implications. 

Scientists have created a compact machine that can churn out thousands of doses of prescription medication in a day—putting the capabilities of a drug-manufacturing plant into a device the size of a kitchen refrigerator.

Experts said the advance could eventually allow on-the-spot drug production in special circumstances—on the battlefield, during epidemics, after natural disasters, or in cases where a drug is needed for a rare medical condition, for instance.

The research, detailed in the April 1 issue of Science, took a new approach to producing prescription drugs—which, right now, is often an inefficient, time-consuming process.

Chemical engineers at the Massachusetts Institute of Technology (MIT) used so-called "flow technology" to develop a compact machine that can automatically turn raw materials into a finished pharmaceutical-grade medication.

For now, the system is limited to making liquid versions of four common prescription drugs: the antidepressant fluoxetine (Prozac); diphenhydramine hydrochloride, an antihistamine that includes brand-names like Benadryl; the sedative diazepam (Valium); and lidocaine, a widely used local anesthetic.

But the researchers say that drug list can be expanded.

"We're also working on producing tablets, which are more complicated to manufacture than liquid drug formulations," said Klavs Jensen, a professor of chemical engineering at MIT who worked on the study.

Other technologies—such as 3D "bioprinters"—could help make that happen, according to Jensen.

Many drug companies are already looking into alternative processing methods—ones that are "continuous" and can be done at one location, Jensen said.

The traditional way of drug-making is similar to cooking, according to Rainer Martin, a senior scientist with drug company Hoffmann-La Roche, in Basel, Switzerland.

Martin, who wrote an editorial published with the study, explained the process this way: Drugs are made in "batches," and the ingredients—broad groups of chemicals known as reagents, catalysts and solvents—are gradually added into a vat, stirred and heated. Then, the brew is analyzed to see if the chemical reactions are complete.

The problem, Jensen said, is that batch manufacturing has "little flexibility to respond to surges in demand"—such as epidemics. Plus, he added, there can be "severe disruptions" in the drug supply if one plant has to shut down.

The compact system his team developed is continuous, Jensen explained. Chemical reactions take place as chemicals flow through small tubes, instead of sitting in large vats.

The result, according to Martin, is that complex and "laborious" drug-making steps are all done in "fully automated fashion."

Martin said he could envision the compact system being used in a number of scenarios: During a disease outbreak in a refugee camp or remote area, for example, or by individual hospitals that need large amounts of a particular drug on a regular basis.

Matthew Osterhaus, immediate past president of the American Pharmacists Association, agreed that the technology might prove useful in special circumstances.

As an example, he pointed to "orphan drugs"—medications used to treat rare diseases. "Let's say there's a condition that's treated at five medical centers in the U.S.," Osterhaus said. "It's possible those hospitals would be able to use this."

Top Reddit comment: Perhaps piracy is what it will take to lower drug costs.

Perhaps it will. And perhaps it is time for that to start to happen.

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