It's from the movie Assassins with Sly Stallone.

Last of Us LEGO Joel makes the same reaction:

Thank you matt01ss for making this gif.

Source:

http://www.reddit.com/r/HighQualityGifs/comments/1t93cb/last_of_us_lego_joel_remake/

That starts off an amazing Reddit reaction gifs thread:

http://reddit.com/r/reactiongifs/comments/1t64xg/mrw_my_6_year_old_son_builds_a_lego_masterpiece/

Whoa. A reaction to the reaction:

Source:

http://www.reddit.com/r/reactiongifs/comments/1t64xg/mrw_my_6_year_old_son_builds_a_lego_masterpiece/ce4u4ja

Found here:

http://www.reddit.com/r/reactiongifs/comments/20fqtn/mrw_i_find_out_a_friends_reddit_username_and_hes/cg30h56

CG version featuring Joel (main character of TLU) made by naughty dog, the creators of The Last of Us. They made a recreation for an award they won and because the original GIF is/was used for Playstation related stuff.

Found here:

http://reddit.com/r/reactiongifs/comments/20fqtn/mrw_i_find_out_a_friends_reddit_username_and_hes/cg339yp

Antonio Banderas computer Dickbutt gif: 

Thank you The_Love_Child for this gif:

http://reddit.com/r/HighQualityGifs/comments/31q7v5/the_illuminati_are_fucking_with_tom_cruise/

Tom Cruise Illuminati Eyes Wide Shut dickbutt gif: http://i.imgur.com/NTzuhhr.gifv

Thank you xellellex for making this gif:

http://reddit.com/r/HighQualityGifs/comments/31q7v5/the_illuminati_are_fucking_with_tom_cruise/

That's enough Internet for today.

http://pandawhale.com/post/25234/thats-enough-internet-for-today-gif-shut-down-the-computer-laptop-and-sleep

More computer reaction faces:

http://pandawhale.com/post/1592/computer-reaction-face